Blar i forfatter "Lantto, Juulia"

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    • Effects of nifedipine and sildenafil on placental hemodynamics and gas exchange during fetal hypoxemia in a chronic sheep model 

      Alanne, Leena; Bhide, Amarnath; Hoffren, Jonna; Lantto, Juulia; Huhta, Heikki; Kokki, Merja; Haapsamo, Mervi; Acharya, Ganesh; Rasanen, Juha (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-16)
      Introduction - We hypothesized that nifedipine and sildenafil would have no detrimental effects on placental hemodynamics and gas exchange under fetal hypoxemia.<p> <p>Methods - In 33 chronically instrumented fetal sheep, placental volume blood flow (QPlac) and umbilical artery (UA) vascular impedance were measured by Doppler ultrasonography. Fetal carotid artery blood pressure and blood gas ...

    • Nifedipine disturbs fetal cardiac function during hypoxemia in a chronic sheep model at near term gestation 

      Alanne, Leena; Bhide, Amarnath Govind; Lantto, Juulia; Huhta, Heikki; Kokki, Merja; Haapsamo, Mervi; Acharya, Ganesh; Rasanen, Juha (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11)
      Background: Nifedipine is a widely used drug in pregnancies complicated by maternal hypertensive disorders that can be associated with placental insufficiency and fetal hypoxemia. The evidence regarding fetal myocardial responses to nifedipine in hypoxemia is limited.<p> <p>Objective: We hypothesized that nifedipine would not impair fetal sheep cardiac function under hypoxemic environment. In ...

    • Peripheral chemoreflex activation and cardiac function during hypoxemia in near-term fetal sheep without placental compromise 

      Lantto, Juulia; Erkinaro, Tiina; Haapsamo, Mervi; Huhta, Heikki; Alanne, Leena; Kokki, Merja; Ohtonen, Pasi; Bhide, Amarnath; Acharya, Ganesh; Rasanen, Juha (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-09)
      A drop in arterial oxygen content activates fetal chemoreflex including an increase in sympathetic activity leading to peripheral vasoconstriction and redistribution of blood flow to protect the brain, myocardium, and adrenal glands. By using a chronically instrumented fetal sheep model with intact placental circulation at near-term gestation, we investigated the relationship between peripheral ...